PROJECT 5

EVIDENCE-BASED MEDICINE (CLINICAL OUTCOMES RESEARCH)

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Evidential Reasoning Operations
The following evidential reasoning operations, supported by Gister-CL, are theoretically sound yet have intuitive appeal.

The Evidence-Based Medicine and Set-Theoretic framework based on D-S Mathematical Theory of Evidence is described here –

PROPOSED: Data Mining utilizing Demptster-Shafer Mathematical Theory of Evidence combined with Rough Set Theory

  1. Certainty assigned to a piece of evidence (expresses the degree of confidence that a system has in its observations of the evidence)
  2. Certainty assigned to a mapping (expresses the degree of confidence that an expert has in his definition of the mapping)
  3. R: I » O Combining ( 1 ) and ( 2) a knowledge processing scheme deduces the most likely hypothesis (conclusion)

The practice of Evidenced-Based Medicine (EBM) is triggered by patient encounters which generates questions (queries) about

  1. effect of therapy
  2. utility of diagnostic tests
  3. prognosis of diseases
  4. etiology of disorders

EBM requires –

  1. new skills of clinicians
  2. efficient literature-searching
  3. application of formal rules of evidence in evaluating the clinical literature

Evidence-Based Medical / Clinical Evidence practice includes the integration of clinical expertise, patient values, and the best evidence into the decision making process for patient care.

  • Clinical expertise   »   clinician’s cumulated experience, education, and clinical Skill
  • Patient values   »   personal and unique concerns, expectation and values
  • Best evidence   »   found in clinically relevant research that has been conducted using sound methodology
Full integration of these components into the clinical decisions enhances the opportunity for optimal clinical outcomes and quality.

I propose to utilize the combination of Dempster-Shafer Mathematical Theory of Evidence and Rough Set Theory to assist in this integration effort as part of the data mining component of EBM.


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